The 2011 Yearbook of Physical Anthropology published an appraisal by Harper, Kristin N., et al., of previous studies and stated that the "skeletal data bolsters the case that syphilis did not exist in Europe before Columbus set sail." The scientific evidence as determined by a systematic review of 54 previously published, peer-reviewed instances lends support to the theory that syphilis was unknown in Europe until Columbus returned from the Americas.
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